Dimethyl Sulfoxide → HCID 57911426, compound

HRID 1099167Notes

Reaction equation

HRID 1099167 reaction equation
C(Cl)(=O)C(Cl)=O.C(Cl)Cl.CS(C)=O.[CH:14]([Si:17]([CH:34]([CH3:36])[CH3:35])([CH:31]([CH3:33])[CH3:32])[O:18][CH:19]1[C:25]2=[N:26][CH:27]=[CH:28][CH:29]=[C:24]2[CH2:23][CH:22]([OH:30])[CH2:21][CH2:20]1)([CH3:16])[CH3:15]>O>[CH:34]([Si:17]([CH:14]([CH3:16])[CH3:15])([CH:31]([CH3:33])[CH3:32])[O:18][CH:19]1[C:25]2=[N:26][CH:27]=[CH:28][CH:29]=[C:24]2[CH2:23][C:22](=[O:30])[CH2:21][CH2:20]1)([CH3:36])[CH3:35]

Participants

6

Reactant 4

HCID 679Dimethyl SulfoxideHCID 6344DichloromethaneHCID 65578Oxalyl chlorideHCID 57911408HCID 57911408, compound

Product 1

HCID 57911426HCID 57911426, compoundYield 18.4%

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Conditions

Temperature
-60 °C

Procedure

In an oven dried 500 mL round bottom flask was charged with OXALYL CHLORIDE (6.49 mL, 72.9 mmol), CH2Cl2 (150 mL) under N2. The flask was cooled to −60° C. and DMSO (6.90 mL, 97 mmol) was added to the reaction mixture dropwise. After finish addition, the reaction was stirred at −60° C. for 30 min before cannula the 9-(triisopropylsilyloxy)-6,7,8,9-tetrahydro-5H-cyclohepta[b]pyridin-6-ol (8.1557 g, 24.31 mmol) (dissolved in 20 mL CH2Cl2 and rinsed with 20 mL CH2Cl2) to the reaction mixture at −60° C. The reaction was stirred at −55° C. for 40 min before addition of TEA (16.94 mL, 122 mmol). The reaction seems formed a thick suspension. The reaction was stirred for 1 hour and water was added to the reaction mixture. The organic layer was separated and the aqueous layer was extract by CH2Cl2 twice. The CH2Cl2 layer was combined, dried (Na2SO4), filtered and concentrated. Flash column by ethyl acetate in hexane from 25% to 50% gave the product as yellow oil (1.49 g, 18.4%). MS (ESI)[M+H+]=334.30; 1H NMR (400 MHz, CHLOROFORM-d) δ ppm 8.36 (d, J=5.04 Hz, 1H) 7.46 (d, J=7.55 Hz, 1H) 7.16 (dd, J=7.55, 4.78 Hz, 1H) 5.22 (dd, J=4.78, 2.27 Hz, 1H) 4.66 (d, J=14.35 Hz, 1H) 3.26 (d, J=14.60 Hz, 1H) 2.94-3.05 (m, 1H) 2.42-2.55 (m, 1H) 2.36 (dd, J=14.10, 5.04 Hz, 1H) 2.03-2.17 (m, 1H) 1.03-1.16 (m, 3H) 0.96-1.00 (m, 9H) 0.89-0.92 (m, 9H).

Workup

  1. customIn an oven dried 500 mL round bottom flask
  2. additionAfter finish addition
  3. customThe reaction seems formed a thick suspension
  4. customThe organic layer was separated
  5. extractionthe aqueous layer was extract by CH2Cl2 twice
  6. dry with materialdried (Na2SO4)
  7. filtrationfiltered
  8. concentrationconcentrated

Sources & evidence

ORD record
ord-e4654bea26354aa7b9c477df1f4d9bc9
Source dataset
uspto-grants-2012_03
Patent number
US08143403B2

Reaction notes

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