Hydrazine hydrate (1:1) → HCID 25127837, compound

HRID 1099355Notes

Reaction equation

HRID 1099355 reaction equation
C([O:3][C:4](=O)[CH2:5][N:6]1[C:10]([CH2:11][CH3:12])=[C:9]([CH2:13][C:14]2[CH:22]=[C:21]([CH3:23])[C:20]([O:24][CH3:25])=[C:19]3[C:15]=2[CH2:16][CH2:17][CH2:18]3)[C:8]([CH2:26][CH3:27])=[N:7]1)C.O.[NH2:30][NH2:31]>O>[CH2:26]([C:8]1[C:9]([CH2:13][C:14]2[CH:22]=[C:21]([CH3:23])[C:20]([O:24][CH3:25])=[C:19]3[C:15]=2[CH2:16][CH2:17][CH2:18]3)=[C:10]([CH2:11][CH3:12])[N:6]([CH2:5][C:4]([NH:30][NH2:31])=[O:3])[N:7]=1)[CH3:27]

Participants

4

Reactant 2

HCID 24654Hydrazine hydrate (1:1)HCID 66812250HCID 66812250, compound

Product 1

HCID 25127837HCID 25127837, compoundYield 91.4%

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Conditions

Temperature
62.5 °C

Procedure

A stirred suspension of [3,5-Diethyl-4-(7-methoxy-6-methyl-indan-4-ylmethyl)-pyrazol-1-yl]-acetic acid ethyl ester (3.3 gm, 0.0085 mole) and 99% Hydrazine hydrate (33 ml) was heated at 60-65° C. for 3 hours. The reaction mixture was poured into water (200 ml), stirred for an hour and then filtered. The obtained solid was stirred in Methanol (10 ml), filtered and dried to give 2.9 gm of desired product as a solid.

Workup

  1. filtrationfiltered
  2. stirringThe obtained solid was stirred in Methanol (10 ml)
  3. filtrationfiltered
  4. customdried

Sources & evidence

ORD record
ord-15c9ddb0b9b24fa0be33f662a5f8b7ad
Source dataset
uspto-grants-2012_03
Patent number
US08143424B2

Reaction notes

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