HuagongsheHuagongshe Chemistry Print Report · For research reference only
5-Bromo-2-ethoxypyrimidine → HCID 25115370, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 5-Bromo-2-ethoxypyrimidine | HCID 16427141 | — |
| Reactant | (S)-N,N-dibenzyl-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)chroman-3-amine | HCID 25114260 | — |
| Product | HCID 25115370 | HCID 25115370 | 62% |
Reaction Steps
The title compound was synthesized as described for Intermediate example I-28 in 62% yield starting from (3S)-N,N-dibenzyl-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan -2-yl)chroman-3-amine and 5-bromo-2-ethoxypyrimidine. The reaction mixture was irradiated in a microwave at 140° C. for 20 min; MS (ESI) m/z 452[M+H+].
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08143408B2 |
| Source dataset | uspto-grants-2012_03 |
| ORD ID | ord-166ac06cbb5a42feb604d01d1e33179a |
| Source note | uspto-grants-2012_03 |