4-Bromopyridazine → (2R)-N,N-dibenzyl-8-pyridazin-4-yl-1,2,3,4-tetrahydronaphthalen-2-amine

Participants

Reaction Steps

The title compound was synthesized as described for Intermediate example I-48 in 45% yield starting from [(7R)-7-(dibenzylamino)-5,6,7,8-tetrahydronaphthalen-1-yl]boronic acid and 4-bromopyridazine (1 equiv): 1H NMR (400 MHz, CDCl3) δ ppm 9.24 (dd, 1 H), 9.17 (dd, 1 H), 7.31-7.36 (m, 5 H), 7.25-7.30 (m, 4 H), 7.15-7.24 (m, 4 H), 7.00 (dd, 1 H), 3.59-3.70 (m, 4 H), 2.92-3.08 (m, 2 H), 2.69-2.89 (m, 2 H), 2.51-2.62 (m, 1 H), 2.13-2.25 (m, 1 H), 1.71-1.86 (m, 1 H); MS (ESI) m/z 406[M+H+].

Provenance & Evidence