(1-methyl-1H-imidazol-2-yl)methanol → HCID 59354906, compound

HRID 1099446Notes

Reaction equation

HRID 1099446 reaction equation
Cl[C:2]1[CH:12]=[CH:11][C:5]([C:6]([O:8]CC)=[O:7])=[CH:4][N:3]=1.[CH3:13][N:14]1[CH:18]=[CH:17][N:16]=[C:15]1[CH2:19][OH:20]>>[CH3:13][N:14]1[CH:18]=[CH:17][N:16]=[C:15]1[CH2:19][O:20][C:2]1[CH:12]=[CH:11][C:5]([C:6]([OH:8])=[O:7])=[CH:4][N:3]=1

Participants

3

Reactant 2

HCID 573612(1-methyl-1H-imidazol-2-yl)methanolHCID 2799611Ethyl 6-chloronicotinate

Product 1

HCID 59354906HCID 59354906, compoundYield 46%

Procedure

The title compound was synthesized as described for Intermediate example I-92 in 46% yield starting from ethyl 6-chloronicotinate and (1-methyl-1h-imidazol-2-yl)methanol; 1H NMR (400 MHz, DMSO-d6) δ ppm 8.74 (d, 1 H), 8.24 (dd, 1 H), 7.58-7.74 (m, 2 H), 7.06 (d, 1 H), 5.69 (s, 2 H), 3.92 (s, 3 H); MS (APPI/APCI) m/z 234[M+H+].

Sources & evidence

ORD record
ord-913445e61ecb41819dc4ebd404351597
Source dataset
uspto-grants-2012_03
Patent number
US08143408B2

Reaction notes

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