反应详情

温度

52.5 °C

A mixture of racemic Voriconazole (5 g, 14.3 mmol) and (1R)-(−)-10-camphorsulfonic acid (3.33 g, 14.3 mmol) in methanol (50 ml) was heated until solution at 50-55° C. The solution was cooled down to 22-24° C., stirred for 2 hours and filtered. A white crystalline solid was isolated.

1. temperatureThe solution was cooled down to 22-24° C.
2. filtrationfiltered
3. customA white crystalline solid was isolated