Voriconazole → Voriconazole (1R)-(-)-10-camphorsulfonate

Participants

Reaction Conditions

Reaction Steps

A mixture of racemic Voriconazole (5 g, 14.3 mmol) and (1R)-(−)-10-camphorsulfonic acid (3.33 g, 14.3 mmol) in methanol (50 ml) was heated until solution at 50-55° C. The solution was cooled down to 22-24° C., stirred for 2 hours and filtered. A white crystalline solid was isolated.

Provenance & Evidence