Salicylaldehyde → 3-(4-methoxybenzylsulfonyl)-2H-chromen-2-one

HRID 1099715Notes

Reaction equation

HRID 1099715 reaction equation
[CH:1](=O)[C:2]1[C:3](=[CH:5][CH:6]=[CH:7][CH:8]=1)[OH:4].[CH3:10][O:11][C:12]1[CH:25]=[CH:24][C:15]([CH2:16][S:17]([CH2:20][C:21](O)=[O:22])(=[O:19])=[O:18])=[CH:14][CH:13]=1>C(O)(=O)C>[CH3:10][O:11][C:12]1[CH:13]=[CH:14][C:15]([CH2:16][S:17]([C:20]2[C:21](=[O:22])[O:4][C:3]3[C:2]([CH:1]=2)=[CH:8][CH:7]=[CH:6][CH:5]=3)(=[O:18])=[O:19])=[CH:24][CH:25]=1

Participants

4

Reactant 2

HCID 6998SalicylaldehydeHCID 120974144-Methoxybenzyl-sulfonylacetic acid

Product 1

HCID 116885123-(4-methoxybenzylsulfonyl)-2H-chromen-2-oneYield 87.5%

Reagents, catalysts & solvents 1

HCID 176Acetic AcidSolvent

Procedure

A solution of salicylaldehyde (1 mmol) and 2-(4-methoxybenzylsulfonyl)acetic acid (1 mmol) in acetic acid (10 mL) was subjected to the General Procedure 2, Method A to generate an 87.5% yield of the title compound; m.p. 194-195° C.

Sources & evidence

ORD record
ord-33756a53963b4ffa81e00f67a40bfe45
Source dataset
uspto-grants-2012_03
Patent number
US08143428B2

Reaction notes

Loading…