Salicylaldehyde → 3-(4-chlorobenzylsulfonyl)-2H-chromen-2-one

HRID 1099718Notes

Reaction equation

HRID 1099718 reaction equation
[CH:1](=O)[C:2]1[C:3](=[CH:5][CH:6]=[CH:7][CH:8]=1)[OH:4].[Cl:10][C:11]1[CH:24]=[CH:23][C:14]([CH2:15][S:16]([CH2:19][C:20](O)=[O:21])(=[O:18])=[O:17])=[CH:13][CH:12]=1>C(O)(=O)C>[Cl:10][C:11]1[CH:24]=[CH:23][C:14]([CH2:15][S:16]([C:19]2[C:20](=[O:21])[O:4][C:3]3[C:2]([CH:1]=2)=[CH:8][CH:7]=[CH:6][CH:5]=3)(=[O:17])=[O:18])=[CH:13][CH:12]=1

Participants

4

Reactant 2

HCID 6998SalicylaldehydeHCID 302767[(4-Chlorobenzyl)sulfonyl]acetic acid

Product 1

HCID 115517413-(4-chlorobenzylsulfonyl)-2H-chromen-2-oneYield 99%

Reagents, catalysts & solvents 1

HCID 176Acetic AcidSolvent

Procedure

A solution of salicylaldehyde (1 mmol) and 2-(4-chlorobenzylsulfonyl)acetic acid (1 mmol) in acetic acid (10 mL) was subjected to the General Procedure 2, Method A to generate a 99% yield of the title compound; m.p. 195-196° C.

Sources & evidence

ORD record
ord-389e427dc08b42349b041459b04383ff
Source dataset
uspto-grants-2012_03
Patent number
US08143428B2

Reaction notes

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