Tetrahydrofuran → 4-chloro-N-[4-(2-(4-[(1-methyl-piperidin-4-ylcarbamoyl)-methyl]-piperazin-1-yl}-2-oxo-ethyl)-thiazol-2-yl]-benzamide

HRID 110037Notes

Reaction equation

HRID 110037 reaction equation
[CH2:37]1[O:38][CH2:39][CH2:40][CH2:41]1.[Cl:1][c:2]1[cH:3][cH:4][c:5]([C:6](=[O:7])[NH:8][c:9]2[s:10][cH:11][c:12]([CH2:14][C:15](=[O:16])[N:17]3[CH2:18][CH2:19][N:20]([CH2:23][C:24](=[O:25])[OH:26])[CH2:21][CH2:22]3)[n:13]2)[cH:27][cH:28]1.[NH2:29][CH:30]1[CH2:31][CH2:32][N:33]([CH3:36])[CH2:34][CH2:35]1>>[Cl:1][c:2]1[cH:3][cH:4][c:5]([C:6](=[O:7])[NH:8][c:9]2[s:10][cH:11][c:12]([CH2:14][C:15](=[O:16])[N:17]3[CH2:18][CH2:19][N:20]([CH2:23][C:24](=[O:26])[NH:29][CH:30]4[CH2:31][CH2:32][N:33]([CH3:36])[CH2:34][CH2:35]4)[CH2:21][CH2:22]3)[n:13]2)[cH:27][cH:28]1

Participants

4

Reactant 3

HCID 8028TetrahydrofuranHCID 27375314-Amino-1-methylpiperidineHCID 59698876(4-{2-[2-(4-Chloro-benzoylamino)-thiazol-4-yl]-acetyl}-piperazin-1-yl)-acetic acid

Product 1

HCID 596988384-chloro-N-[4-(2-(4-[(1-methyl-piperidin-4-ylcarbamoyl)-methyl]-piperazin-1-yl}-2-oxo-ethyl)-thiazol-2-yl]-benzamide

Sources & evidence

ORD record
ord-e82dcb4b9a64466a9a6f2383911cddac
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (2/10)

Reaction notes

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