Triethylamine → HCID 178512637, compound

HRID 1105598Notes

Reaction equation

HRID 1105598 reaction equation
Cl.Cl.[NH:3]([C:7]1[S:8][CH:9]=[C:10]([CH2:12][S:13][CH2:14][CH2:15][NH2:16])[N:11]=1)[C:4]([NH2:6])=[NH:5].[NH:17]([C:21]1[S:22][CH:23]=[C:24]([CH2:26][CH2:27][CH2:28][CH2:29][NH:30][C:31]2[C:34](=O)[C:33](=[O:36])[C:32]=2[O:37]C)[N:25]=1)[C:18]([NH2:20])=[NH:19].C(N(CC)CC)C>CO>[NH:3]([C:7]1[S:8][CH:9]=[C:10]([CH2:12][S:13][CH2:14][CH2:15][NH:16][C:34]2[C:33](=[O:36])[C:32](=[O:37])[C:31]=2[NH:30][CH2:29][CH2:28][CH2:27][CH2:26][C:24]2[N:25]=[C:21]([NH:17][C:18]([NH2:20])=[NH:19])[S:22][CH:23]=2)[N:11]=1)[C:4]([NH2:6])=[NH:5]

Participants

5

Reactant 3

HCID 8471TriethylamineHCID 178478806HCID 178478806, compoundHCID 178493728HCID 178493728, compound

Product 1

HCID 178512637HCID 178512637, compoundYield 53.4%

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

A mixture of 2-guanidino-4-[(2-aminoethyl)-thiomethyl]thiazole dihydrochloride (0.024 g), 1-[4-(2-guanidinothiazol-4-yl)butylamino]-2-methoxycyclobutene-3,4-dione (0.032 g) and triethylamine (0.03 ml) in dry methanol (1 ml) was stirred for 18 hours at room temperature. The white solid was filtered off, washed with methanol and dried in vacuo to give 1-[2-(2-guanidinothiazol-4-ylmethylthio)ethylamino]-2-[4-(2-guanidinothiazol-4-yl)butylamino]cyclobuten-3,4-dione, (0.022 g), m.p. 208°-210°.

Workup

  1. filtrationThe white solid was filtered off
  2. washwashed with methanol
  3. customdried in vacuo

Sources & evidence

ORD record
ord-53088c989e884b2a90a6e8d0cd0167ac
Source dataset
uspto-grants-1982_01
Patent number
US04309435

Reaction notes

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