HRID1105644

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID7912

Diisopropylamine

C6H15N

HCID13506860

2-Methyl-1-sulfanylheptan-2-ol

C8H18OS

结构：O=C(CCCC=CCC1=CC(O)CC1=O)Oc1ccc(NC(=O)c2ccccc2)cc1

HCID57189790

未命名化合物

PRODUCTS

生成物

结构：CCCCCC(C)(O)CS[C@H]1[C@H](O)CC(=O)[C@@H]1CC=CCCCC(=O)Oc1ccc(NC(=O)c2ccccc2)cc1

HCID70554139

未命名化合物

PROCEDURE

实验过程

Analogously to Example 5, by reaction of 7-(3-hydroxy-5-oxo-1-cyclopenten-1-yl)-hept-5-enoic acid p-benzoylaminophenyl ester with 2-hydroxy-2-methyl-heptanethiol in the presence of diisopropylamine, 11α,15-dihydroxy-15-methyl-9-oxo-13-thia-5-prostenoic acid p-benzoylaminophenyl ester is obtained.

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-8b11e128573846898c3a0c8113c8a24b
来源数据集: uspto-grants-1982_01
DOI: 10.6084/m9.figshare.5104873.v1
专利: US04309441
来源说明: uspto-grants-1982_01

反应 SMILES

[C:1]([NH:9][C:10]1[CH:15]=[CH:14][C:13]([O:16][C:17](=[O:31])[CH2:18][CH2:19][CH2:20][CH:21]=[CH:22][CH2:23][C:24]2[C:28](=[O:29])[CH2:27][CH:26]([OH:30])[CH:25]=2)=[CH:12][CH:11]=1)(=[O:8])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[OH:32][C:33]([CH3:41])([CH2:36][CH2:37][CH2:38][CH2:39][CH3:40])[CH2:34][SH:35].C(NC(C)C)(C)C>>[C:1]([NH:9][C:10]1[CH:15]=[CH:14][C:13]([O:16][C:17](=[O:31])[CH2:18][CH2:19][CH2:20][CH:21]=[CH:22][CH2:23][C@@H:24]2[C@@H:25]([S:35][CH2:34][C:33]([OH:32])([CH3:41])[CH2:36][CH2:37][CH2:38][CH2:39][CH3:40])[C@H:26]([OH:30])[CH2:27][C:28]2=[O:29])=[CH:12][CH:11]=1)(=[O:8])[C:2]1[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=1