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HRID1105678

反应详情

EQUATION

反应方程式

HRID 1105678 的结构方程式

REACTANTS

反应物

3
反应SMILES：O=C([O-])[O-].[Na+].[Na+]
HCID10340

Carbonic acid sodium salt (1:2)

CNa2O3

反应SMILES：COc1cc2nc(Cl)nc(N)c2cc1OC
HCID90235

4-Amino-2-chloro-6,7-dimethoxyquinazoline

C10H10ClN3O2

反应SMILES：O=C1c2ccccc2CN1C1CCNCC1
HCID15431961

2-(Piperidin-4-yl)-2,3-dihydro-1H-isoindol-1-one

C13H16N2O

PRODUCTS

产物

1
反应SMILES：COc1cc2nc(N3CCC(N4Cc5ccccc5C4=O)CC3)nc(N)c2cc1OC.Cl
HCID20556257

未命名化合物

AUXILIARIES

试剂、催化剂与溶剂

1
反应SMILES：CN(C)C=O
溶剂HCID6228

Dimethylformamide

C3H7NO

PROCEDURE

实验过程

By heating in an analogous fashion 2.4 g of 4-amino-2-chloro-6,7-dimethoxyquinazoline, 2.2 g of 2-(4-piperidinyl)-isoindolin-1-one, 2.0 g of anhydrous sodium carbonate and 20 ml of dimethylformamide, the 2-[1-(4-amino-6,7-dimethoxy-2-quinazolinyl)-4-piperidinyl]-isoindolin-1-one monohydrochloride is obtained, melting at 288°-289° (dec.).