Chloroform → HCID 20523623, compound

HRID 1105734Notes

Reaction equation

HRID 1105734 reaction equation
ClC1C=CC=C(C(OO)=[O:9])C=1.[C:12]([NH:15][CH:16]1[CH2:44][CH2:43][CH:19]2[CH:20]([CH3:42])[NH:21][C:22]3[C:27]([CH:18]2[CH2:17]1)=[C:26]([O:28][C:29](=[O:31])[CH3:30])[CH:25]=[C:24]([S:32][CH:33]([CH:35]([CH3:41])[CH2:36][CH2:37][CH2:38][CH2:39][CH3:40])[CH3:34])[CH:23]=3)(=[O:14])[CH3:13].C(Cl)(Cl)Cl>C(O)(=O)C>[C:12]([NH:15][CH:16]1[CH2:44][CH2:43][CH:19]2[CH:20]([CH3:42])[NH:21][C:22]3[C:27]([CH:18]2[CH2:17]1)=[C:26]([O:28][C:29](=[O:31])[CH3:30])[CH:25]=[C:24]([S:32]([CH:33]([CH:35]([CH3:41])[CH2:36][CH2:37][CH2:38][CH2:39][CH3:40])[CH3:34])=[O:9])[CH:23]=3)(=[O:14])[CH3:13]

Participants

5

Reactant 3

HCID 6212ChloroformHCID 70297m-Chloroperbenzoic acidHCID 20523622HCID 20523622, compound

Product 1

HCID 20523623HCID 20523623, compound

Reagents, catalysts & solvents 1

HCID 176Acetic AcidSolvent

Procedure

Equimolar amounts of m-chloroperbenzoic acid and dl-9-acetamido-1-acetoxy-6-methyl-3-(3-methyl-2-octylthio)5,6,6a,7,8,9,10,10a-octahydrobenzo[c]quinoline are added to a mixture of chloroform and acetic acid (2:1 v/v) and the mixture stirred at room temperature for one hour. The reaction mixture is washed with water, the organic phase dried over magnesium sulfate and evaporated to dryness at reduced pressure to give the title compound.

Workup

  1. washThe reaction mixture is washed with water
  2. dry with materialthe organic phase dried over magnesium sulfate
  3. customevaporated to dryness at reduced pressure

Sources & evidence

ORD record
ord-93e2f1a18fc44aceb5082c02df7062d5
Source dataset
uspto-grants-1982_01
Patent number
US04309545

Reaction notes

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