Ethyl bromoacetate → 2-Ethoxycarbonylmethoxy-3-(tetrahydropyran-2-yloxy)-nitrobenzene
Reaction equation
[OH:1][C:2]1[C:7]([O:8][CH:9]2[CH2:14][CH2:13][CH2:12][CH2:11][O:10]2)=[CH:6][CH:5]=[CH:4][C:3]=1[N+:15]([O-:17])=[O:16].C(=O)([O-])[O-].[K+].[K+].Br[CH2:25][C:26]([O:28][CH2:29][CH3:30])=[O:27]>C(C(C)=O)C>[CH2:29]([O:28][C:26]([CH2:25][O:1][C:2]1[C:7]([O:8][CH:9]2[CH2:14][CH2:13][CH2:12][CH2:11][O:10]2)=[CH:6][CH:5]=[CH:4][C:3]=1[N+:15]([O-:17])=[O:16])=[O:27])[CH3:30]Participants
Procedure
A mixture of 38.4 g of 2-hydroxy-3-(tetrahydropyran-2-yloxy)-nitrobenzene, 22.2 g of potassium carbonate and 27.0 g of ethyl bromoacetate in 400 ml of methyl ethyl ketone is heated to the reflux temperature for 16 hours, whilst stirring, and then filtered; the filter residue is rinsed with 100 ml of methyl ethyl ketone. The combined filtrates are evaporated under reduced pressure. The residual yellowish oil is taken up in 400 ml of diethyl ether, the solution is clarified by filtration, with the addition of 2 g of an active charcoal formulation and the filtrate is evaporated under reduced pressure. The residual oil solidifies after some time to give a mass of crystals and gives 2-ethoxycarbonylmethoxy-3-(tetrahydropyran-2-yloxy)-nitrobenzene; melting point 65°-66°.
Workup
- temperatureis heated to the reflux temperature for 16 hours
- filtrationfiltered
- washthe filter residue is rinsed with 100 ml of methyl ethyl ketone
- customThe combined filtrates are evaporated under reduced pressure
- filtrationthe solution is clarified by filtration, with the addition of 2 g of an active charcoal formulation
- customthe filtrate is evaporated under reduced pressure
- customto give a mass of crystals
Sources & evidence
- ORD record
- ord-52cff72653db45acb8b2f3f8ff8925a2
- Source dataset
- uspto-grants-1982_01
- Patent number
- US04310527
Reaction notes
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