Hydrazine hydrate (1:1) → HCID 20555063, compound

HRID 1105817Notes

Reaction equation

HRID 1105817 reaction equation
[C:1]([NH:5][CH2:6][CH:7]([OH:21])[CH2:8][O:9][C:10]1[CH:15]=[CH:14][CH:13]=[C:12]([N+:16]([O-])=O)[C:11]=1[C:19]#[N:20])([CH3:4])([CH3:3])[CH3:2].[OH2:22].NN>C(O)C.[Ni]>[C:1]([NH:5][CH2:6][CH:7]([OH:21])[CH2:8][O:9][C:10]1[CH:15]=[CH:14][CH:13]=[C:12]([NH2:16])[C:11]=1[C:19]([NH2:20])=[O:22])([CH3:4])([CH3:3])[CH3:2]

Participants

5

Reactant 2

HCID 24654Hydrazine hydrate (1:1)HCID 20555050HCID 20555050, compound

Product 1

HCID 20555063HCID 20555063, compound

Reagents, catalysts & solvents 2

HCID 935NickelCatalystHCID 702EthanolSolvent

Procedure

12.2 g of 1-tert.-butylamino-3-(2-cyano-3-nitrophenoxy)-2-propanol are reacted in 200 ml of ethanol with 11 g of hydrazine hydrate and Raney nickel, analogously to Example 4(d), and after filtering and evaporating the filtrate, this gives crude 6-(3-tert.-butylamino-2-hydroxy-propoxy)-anthranilamide in the form of an oil which is used further without further purification.

Workup

  1. filtrationafter filtering
  2. customevaporating the filtrate

Sources & evidence

ORD record
ord-a6ddd061a1484dc3bfa0b6060bfb17fe
Source dataset
uspto-grants-1982_01
Patent number
US04310527

Reaction notes

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