HCID 20555057, compound → HCID 20555068, compound

HRID 1105827Notes

Reaction equation

HRID 1105827 reaction equation
C([NH:8][CH2:9][CH:10]([OH:23])[CH2:11][O:12][C:13]1[C:21]2[C:17](=[N:18][C:19](=[O:22])[N:20]=2)[CH:16]=[CH:15][CH:14]=1)C1C=CC=CC=1.[H][H]>[Pd].CO>[NH2:8][CH2:9][CH:10]([OH:23])[CH2:11][O:12][C:13]1[C:21]2[C:17](=[N:18][C:19](=[O:22])[N:20]=2)[CH:16]=[CH:15][CH:14]=1

Participants

5

Reactant 2

HCID 20555057HCID 20555057, compoundHCID 178418361HCID 178418361, compound

Product 1

HCID 20555068HCID 20555068, compound

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 887MethanolSolvent

Procedure

1.6 g of palladium-on-charcoal catalyst are added to a solution of 15.5 g of 4-(3-benzylamino-2-hydroxypropoxy)benzimidazol-2-one in 160 ml of methanol, and the mixture is hydrogenated until the calculated amount of hydrogen has been absorbed. The catalyst is filtered off and the solvent distilled off to leave 4-(3-amino-2-hydroxypropoxy)-benzimidazol-2-one, which melts at 188°-190° after recrystallization from ethanol.

Workup

  1. customhas been absorbed
  2. filtrationThe catalyst is filtered off
  3. distillationthe solvent distilled off

Sources & evidence

ORD record
ord-e520b76ae9b3489d960f5f6eaa55be7c
Source dataset
uspto-grants-1982_01
Patent number
US04310527

Reaction notes

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