HuagongsheHuagongshe Chemistry Print Report · For research reference only
HCID 20555057, compound → HCID 20555068, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | HCID 20555057 | HCID 20555057 | — |
| Reactant | HCID 178418361 | HCID 178418361 | — |
| Catalyst | Palladium | HCID 23938 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | HCID 20555068 | HCID 20555068 | — |
Reaction Steps
1.6 g of palladium-on-charcoal catalyst are added to a solution of 15.5 g of 4-(3-benzylamino-2-hydroxypropoxy)benzimidazol-2-one in 160 ml of methanol, and the mixture is hydrogenated until the calculated amount of hydrogen has been absorbed. The catalyst is filtered off and the solvent distilled off to leave 4-(3-amino-2-hydroxypropoxy)-benzimidazol-2-one, which melts at 188°-190° after recrystallization from ethanol.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04310527 |
| Source dataset | uspto-grants-1982_01 |
| ORD ID | ord-e520b76ae9b3489d960f5f6eaa55be7c |
| Source note | uspto-grants-1982_01 |