反应详情

2,3,4-Tri-O-acetyl-1-thio-β-L-fucopyranose (10 mmol) is treated with 6-(5-cholesten-3β-yloxy)hexyl iodide (10 mmol) in dichloromethane (30 ml) containing triethylamine (10 mmol). The reaction takes place in 1 day at room temperature under nitrogen. The resulting solution is washed with distilled water (20 ml) and dried with anhydrous sodium sulfate. The filtered solution is concentrated to form a syrup which is put on a silica gel column and eluted with chloroform followed by 1.0% ethanol in chloroform. The fractions containing the title compound, as determined by thin layer chromatography, are pooled and evaporated to give the title compound in 61% yield [α]D -4° (c 1.5, chloroform).

1. customin 1 day
2. customat room temperature
3. washThe resulting solution is washed with distilled water (20 ml)
4. dry with materialdried with anhydrous sodium sulfate
5. concentrationThe filtered solution is concentrated
6. customto form a syrup which
7. washeluted with chloroform
8. additionThe fractions containing the title compound
9. customevaporated