Benzene → HCID 12882430, compound

HRID 1105937Notes

Reaction equation

HRID 1105937 reaction equation
[CH:1]1C=CC=CC=1.[C:7]([O:11][CH3:12])(=[O:10])[CH:8]=[CH2:9].[CH3:13][C@H:14]([NH2:23])[C@H:15]([OH:22])[C:16]1[CH:21]=[CH:20][CH:19]=[CH:18][CH:17]=1.C=O>O>[CH3:12][O:11][C:7](=[O:10])[CH2:8][CH2:9][N:23]1[CH:14]([CH3:13])[CH:15]([C:16]2[CH:17]=[CH:18][CH:19]=[CH:20][CH:21]=2)[O:22][CH2:1]1

Participants

6

Reactant 4

HCID 241BenzeneHCID 712FormaldehydeHCID 7294Methyl AcrylateHCID 10297Phenylpropanolamine

Product 1

HCID 12882430HCID 12882430, compound

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

200 ml of benzene, 43 g. (0.5 moles) of methyl acrylate and 76 g. of l-norephedrine are added to a 500 ml. three neck flask and refluxed overnight. To the solution is slowly added 15 g. (0.5 moles) of paraformaldehyde and the water removed using a Dean-Stark head. Concentrate the solution in vacuo on a steam bath and distill. The product boils at 137°-139° C./0.5 mm. The yield is 62 g.; n24 d=1.5155.

Workup

  1. temperaturethree neck flask and refluxed overnight
  2. concentrationConcentrate the solution in vacuo on a steam bath
  3. distillationdistill

Sources & evidence

ORD record
ord-d4906007a8fa4bc58e5336ee0a2c1c0a
Source dataset
uspto-grants-1982_01
Patent number
US04310674

Reaction notes

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