Diazomethane → HCID 14036305, compound

HRID 1106088Notes

Reaction equation

HRID 1106088 reaction equation
[C:1]([S:4][CH2:5][CH:6]([CH3:21])[C:7]([N:9]1[CH2:16][C:15]([O:19][CH3:20])([O:17][CH3:18])[CH2:14][C@H:10]1[C:11]([OH:13])=[O:12])=[O:8])(=[O:3])[CH3:2].[N+](=[CH2:24])=[N-]>CCOCC>[C:1]([S:4][CH2:5][CH:6]([CH3:21])[C:7]([N:9]1[CH2:16][C:15]([O:17][CH3:18])([O:19][CH3:20])[CH2:14][C@H:10]1[C:11]([O:13][CH3:24])=[O:12])=[O:8])(=[O:3])[CH3:2]

Participants

4

Reactant 2

HCID 9550DiazomethaneHCID 12821144HCID 12821144, compound

Product 1

HCID 14036305HCID 14036305, compound

Reagents, catalysts & solvents 1

HCID 3283Diethyl EtherSolvent

Procedure

A solution of the product from Example 3 in ether is treated with a slight excess of diazomethane. After standing at room temperature, the solvent is evaporated to give (S)-1-[3-(acetylthio)-2-methyl-1-oxopropyl]-4,4-dimethoxy-L-proline, methyl ester.

Workup

  1. customAfter standing at room temperature
  2. customthe solvent is evaporated

Sources & evidence

ORD record
ord-dd0eaf28330e4cad9a3a0e508592fd54
Source dataset
uspto-grants-1982_01
Patent number
US04311697

Reaction notes

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