反应详情

A solution of 10 g. of ethyl 4-[(11-bromoundecyl)amino]benzoate and 2.0 g. of thiourea in 80% of 95% ethanol is stirred under reflux for 3 hours, allowed to cool, treated with 12 ml. of 10 N aqueous sodium hydroxide solution and again stirred under reflux for 2 hours. The mixture is acidified with dilute hydrochloric acid and filtered. The solid is recrystallized from ethanol-water to yield the product as a white solid.

1. temperatureunder reflux for 3 hours
2. temperatureto cool
3. additiontreated with 12 ml
4. temperatureunder reflux for 2 hours
5. filtrationfiltered
6. customThe solid is recrystallized from ethanol-water