Hydrochloric Acid → HCID 12832224, compound

HRID 1106184Notes

Reaction equation

HRID 1106184 reaction equation
C([NH:4][C:5]1[CH:6]=[C:7]([C:11]2[NH:12][C:13](=[O:19])[C:14](=[CH:17][CH:18]=2)[C:15]#N)[CH:8]=[CH:9][CH:10]=1)(=O)C.[OH-:20].[K+].Cl.[OH-:23].[Na+]>O>[NH2:4][C:5]1[CH:6]=[C:7]([C:11]2[NH:12][C:13](=[O:19])[C:14](=[CH:17][CH:18]=2)[C:15]([OH:23])=[O:20])[CH:8]=[CH:9][CH:10]=1

Participants

6

Reactant 4

HCID 313Hydrochloric AcidHCID 14797Potassium HydroxideHCID 14798Sodium HydroxideHCID 12918955HCID 12918955, compound

Product 1

HCID 12832224HCID 12832224, compound

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

A mixture of 92.5 g (0.37 mol) of 6-(3-acetylaminophenyl)-1,2-dihydro-2-oxonicotinonitrile, 185 g of potassium hydroxide, and 740 ml of water is heated at 105° for 30 hrs. The cooled reaction mixture is poured into 285 ml of concentrated hydrochloric acid and ice. The pH of the suspension is adjusted to 5.0 with aqueous sodium hydroxide solution and the solid filtered, washed with water, and dried to give 81.2 g of 6-(3-aminophenyl)-1,2-dihydro-2-oxonicotinic acid. ##EQU49##

Workup

  1. temperatureis heated at 105° for 30 hrs
  2. customThe cooled reaction mixture
  3. filtrationthe solid filtered
  4. washwashed with water
  5. customdried

Sources & evidence

ORD record
ord-897e7e463831421ab715dca5976fb9aa
Source dataset
uspto-grants-1982_01
Patent number
US04311698

Reaction notes

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