Water → HCID 20553700, compound

HRID 1106232Notes

Reaction equation

HRID 1106232 reaction equation
[F:1][C:2]1[CH:3]=[C:4]([NH2:15])[C:5](=[CH:9][C:10]=1[S:11](=[O:14])(=[O:13])[NH2:12])[C:6]([OH:8])=[O:7].O.[C:17](=O)([O-])[O-].[K+].[K+]>CO.S(=O)(=O)(O)O>[NH2:15][C:4]1[CH:3]=[C:2]([F:1])[C:10]([S:11](=[O:13])(=[O:14])[NH2:12])=[CH:9][C:5]=1[C:6]([O:8][CH3:17])=[O:7]

Participants

6

Reactant 3

HCID 962WaterHCID 11430Potassium CarbonateHCID 205536982-AMINO-5-(AMINOSULFONYL)-4-FLUOROBENZOIC ACID

Product 1

HCID 20553700HCID 20553700, compound

Reagents, catalysts & solvents 2

HCID 887MethanolSolvent2×HCID 1118Sulfuric AcidSolvent

Procedure

A reaction flask, containing 7.2 g (0.0307 molecule) of 4-fluoro-5-sulphamylanthranilic acid (6) in 125 ml of methanol and 10 ml of concentrated sulphuric acid, was attached to a Soxhlet apparatus, containing molecular sieves 4A, immersed in methanol (25 ml). After 48 hours' reflux, the solution was poured into cold water (500 ml), containing 25 g of potassium carbonate. The solid, which separated out, was recovered on a filter and dried in vacuo at 80°; yield: 5.6 g (73.7%); m.p.: 209°-211°.

Workup

  1. temperatureAfter 48 hours' reflux
  2. customThe solid, which separated out
  3. customwas recovered on
  4. filtrationa filter
  5. customdried in vacuo at 80°

Sources & evidence

ORD record
ord-b8499628158a4cf09f10c013b10b43d7
Source dataset
uspto-grants-1982_01
Patent number
US04312862

Reaction notes

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