Dimethyl Sulfate → HCID 12909448, compound

HRID 1106246Notes

Reaction equation

HRID 1106246 reaction equation
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([N:8]2[C:20](=[O:21])[C:11]3=[CH:12][NH:13][C:14]4[CH:15]=[CH:16][CH:17]=[CH:18][C:19]=4[C:10]3=[N:9]2)=[CH:4][CH:3]=1.S(OC)(O[CH3:26])(=O)=O>>[CH3:26][N:9]1[C:10]2[C:19]3[CH:18]=[CH:17][CH:16]=[CH:15][C:14]=3[N:13]=[CH:12][C:11]=2[C:20](=[O:21])[N:8]1[C:5]1[CH:6]=[CH:7][C:2]([Cl:1])=[CH:3][CH:4]=1

Participants

3

Reactant 2

HCID 6497Dimethyl SulfateHCID 178515186HCID 178515186, compound

Product 1

HCID 12909448HCID 12909448, compound

Procedure

The mixture of 3.0 g of 2-(p-chlorophenyl)-pyrazolo[4,3-c]quinolin-3(5H)-one and 100 ml of dimethyl sulfate is stirred at 110°-130° for 2 hours and evaporated. The residue is dissolved in N aqueous sodium hydroxide, the solution extracted with methylene chloride and the extract evaporated. The residue is recrystallized from diethyl ether, to yield the 1-methyl-2-(p-chlorophenyl)-pyrazolo[4,3-c]quinolin-3-one melting at 158°-161°.

Workup

  1. customevaporated
  2. dissolutionThe residue is dissolved in N aqueous sodium hydroxide
  3. extractionthe solution extracted with methylene chloride
  4. customthe extract evaporated
  5. customThe residue is recrystallized from diethyl ether

Sources & evidence

ORD record
ord-bbf2d20e90d74694ad1e504e8ccad75d
Source dataset
uspto-grants-1982_01
Patent number
US04312870

Reaction notes

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