反应详情

The mixture of 2.7 g of ethyl 4-chloro-6-methoxyquinolin-3-carboxylate, 1.4 g of p-fluorophenylhydrazine and 20 ml of eutectic diphenyl ether-biphenyl is heated to 160°-165° for 4 hours, then cooled to room temperature and diluted with diethyl ether. The precipitated crystalline product is collected, washed thoroughly with diethyl ether and dried, to yield the 2-(p-fluorophenyl)-8-methoxypyrazolo]4,3-c]quinolin-3(5H)-one hydrochloride melting at 322°-324°.

1. temperatureis heated to 160°-165° for 4 hours
2. customThe precipitated crystalline product is collected
3. washwashed thoroughly with diethyl ether
4. customdried