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The starting material for the latter is prepared as follows: The mixture of 28.9 g of ethyl 6-fluoro-4-hydroxy-quinolin-3-carboxylate [J.A.C.S., 69, 371 (1947)] and 240 ml of phosphorus oxychloride is refluxed under nitrogen for 3 hours. After cooling to room temperature, the solution is evaporated and the residue treated with ice-water and chloroform. The organic layer is dried and evaporated. The residue is taken up in aqueous sodium bicarbonate and diethyl ether, the ethereal layer is dried and evaporated, to yield the ethyl 4-chloro-6-fluoroquinolin-3-carboxylate melting at 55°-57°.

1. customThe starting material for the latter is prepared
2. temperatureis refluxed under nitrogen for 3 hours
3. customthe solution is evaporated
4. additionthe residue treated with ice-water and chloroform
5. customThe organic layer is dried
6. customevaporated
7. dry with materialdiethyl ether, the ethereal layer is dried
8. customevaporated