反应详情

The mixture of 3.0 g of 2-(p-methoxyphenyl)-pyrazolo-[4,3-c]quinolin-3(5H)-one and 260 ml of 48% hydrobromic acid is refluxed for 1 hour and concentrated to about 50 ml. The concentrate is cooled to room temperature, the precipitate collected, washed with methanol and diethyl ether, and dissolved in diluted aqueous sodium hydroxide. The solution is washed with diethyl ether, then its pH adjusted to 8.5 by addition of ammonium chloride, precipitating a solid which is collected, washed with methanol, then with diethyl ether and dried, to yield the 2-(p-hydroxyphenyl)-pyrazolo[4,3-c]quinolin-3(5H)-one melting at 294°-296°.

1. temperatureis refluxed for 1 hour
2. concentrationconcentrated to about 50 ml
3. customthe precipitate collected
4. washwashed with methanol and diethyl ether
5. dissolutiondissolved in diluted aqueous sodium hydroxide
6. washThe solution is washed with diethyl ether
7. additionits pH adjusted to 8.5 by addition of ammonium chloride
8. customprecipitating a solid which
9. customis collected
10. washwashed with methanol
11. dry with materialwith diethyl ether and dried