Hydrogen Peroxide → HCID 178513658, compound

HRID 1106259Notes

Reaction equation

HRID 1106259 reaction equation
[C:1]([C:3]1[CH:8]=[CH:7][C:6]([N:9]2[C:21](=[O:22])[C:12]3=[CH:13][NH:14][C:15]4[CH:16]=[CH:17][CH:18]=[CH:19][C:20]=4[C:11]3=[N:10]2)=[CH:5][CH:4]=1)#[N:2].[OH-:23].[Na+].OO>C(O)C>[C:1]([C:3]1[CH:8]=[CH:7][C:6]([N:9]2[C:21](=[O:22])[C:12]3=[CH:13][NH:14][C:15]4[CH:16]=[CH:17][CH:18]=[CH:19][C:20]=4[C:11]3=[N:10]2)=[CH:5][CH:4]=1)(=[O:23])[NH2:2]

Participants

5

Reactant 3

HCID 784Hydrogen PeroxideHCID 14798Sodium HydroxideHCID 178510016HCID 178510016, compound

Product 1

HCID 178513658HCID 178513658, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

One gram of 2-(p-cyanophenyl)-pyrazolo[4,3-c]quinolin-3(5H)-one, 3.50 ml of 1 N aqueous sodium hydroxide and 10 ml of ethanol are mixed and stirred at room temperature until the solid has dissolved. The solution is then treated with 1.4 ml of 30% hydrogen peroxide, giving an immediate precipitate. After stirring for 2 hours at room temperature, the mixture is filtered, and the solid is crystallized from dimethylformamide, to yield the 2-(p-carbamoylphenyl)-pyrazolo [4,3-c]quinolin-3(5H)-one, showing peaks in the IR-spectrum at 885, 853, 830, 785, 775, 752 and 732 cm-1.

Workup

  1. dissolutionhas dissolved
  2. customgiving an immediate precipitate
  3. stirringAfter stirring for 2 hours at room temperature
  4. filtrationthe mixture is filtered
  5. customthe solid is crystallized from dimethylformamide

Sources & evidence

ORD record
ord-5e9245b80c44439891ca43dfab6ea8ff
Source dataset
uspto-grants-1982_01
Patent number
US04312870

Reaction notes

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