Ethylene Glycol → HCID 15790821, compound

HRID 1106399Notes

Reaction equation

HRID 1106399 reaction equation
[Cl:1][C:2]1[C:3]([N:12]2[C:16]([CH:17]=[O:18])=[C:15]([C:19]#[N:20])[CH:14]=[N:13]2)=[N:4][N:5]([CH3:11])[C:6]=1[O:7][CH:8]([F:10])[F:9].[CH2:21](O)[CH2:22][OH:23].C1(C)C=CC(S(O)(=O)=O)=CC=1.O>C1(C)C=CC=CC=1>[Cl:1][C:2]1[C:3]([N:12]2[C:16]([CH:17]3[O:23][CH2:22][CH2:21][O:18]3)=[C:15]([C:19]#[N:20])[CH:14]=[N:13]2)=[N:4][N:5]([CH3:11])[C:6]=1[O:7][CH:8]([F:10])[F:9]

Participants

6

Reactant 4

HCID 174Ethylene GlycolHCID 962WaterHCID 6101p-Toluenesulfonic acidHCID 15790818HCID 15790818, compound

Product 1

HCID 15790821HCID 15790821, compound

Reagents, catalysts & solvents 1

HCID 1140TolueneSolvent

Procedure

0.6 g (2.0 mmol) 1-(4-chlor-5-difluormethoxy-1-methyl-3pyrazolyl)-5-formyl-4-pyrazol-carbonitrile is dissolved in 30 ml toluene and 0.14 g (2.2 mmol) ethylene glycol and a catalytic amount of p-toluene sulphonic acid are added. The mixture is heated for 2 hours on the water-separator, the cooled solution is washed with sodium chloride solution, and it is then dried and concentrated.

Workup

  1. washthe cooled solution is washed with sodium chloride solution, and it
  2. customis then dried
  3. concentrationconcentrated

Sources & evidence

ORD record
ord-17e6906cc37a48328e3054442a9070f1
Source dataset
uspto-grants-2000_05
Patent number
US06057270

Reaction notes

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