Water → HCID 21704311, compound

HRID 1106416Notes

Reaction equation

HRID 1106416 reaction equation
C([O:3][P:4]([C:7]1[CH:12]=[CH:11][C:10]([CH2:13][N:14]2[C:23]3[C:18](=[CH:19][C:20]([N+:24]([O-:26])=[O:25])=[CH:21][CH:22]=3)[NH:17][C:16](=[O:27])[C:15]2=[O:28])=[CH:9][CH:8]=1)(=[O:6])[OH:5])C.O>Cl>[N+:24]([C:20]1[CH:19]=[C:18]2[C:23](=[CH:22][CH:21]=1)[N:14]([CH2:13][C:10]1[CH:9]=[CH:8][C:7]([P:4](=[O:3])([OH:5])[OH:6])=[CH:12][CH:11]=1)[C:15](=[O:28])[C:16](=[O:27])[NH:17]2)([O-:26])=[O:25]

Participants

4

Reactant 2

HCID 962WaterHCID 53741756HCID 53741756, compound

Product 1

HCID 21704311HCID 21704311, compoundYield 47.9%

Reagents, catalysts & solvents 1

HCID 313Hydrochloric AcidSolvent

Procedure

582 mg (1.4 mmol) of 4-(6-nitro-2,3-dioxo-1,2,3,4-tetrahydroquinoxalin-1-ylmethyl)phenylphosphonic acid ethyl ester is refluxed in 6 ml of concentrated hydrochloric acid for 2 hours. After cooling, the batch is combined with water and suctioned off. The filter cake is dried, thus obtaining 253 mg of 4-(6-nitro-2,3-dioxo-1,2,3,4-tetrahydroquinoxalin-1-ylmethyl)phenylphosphonic acid, mp: 253-265° C. with decomposition.

Workup

  1. temperatureAfter cooling
  2. customThe filter cake is dried

Sources & evidence

ORD record
ord-a222735708e8494387c3f3d4802ef6d4
Source dataset
uspto-grants-2000_05
Patent number
US06057304

Reaction notes

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