Hydrochloric Acid → HCID 21253082, compound

HRID 1106434Notes

Reaction equation

HRID 1106434 reaction equation
C([N:4]1[CH2:13][CH2:12][C:11]2[C:6](=[C:7]([Br:21])[CH:8]=[C:9]([N+:18]([O-:20])=[O:19])[C:10]=2[NH:14]C(=O)C)[CH2:5]1)(=O)C.[ClH:22]>>[ClH:22].[Br:21][C:7]1[C:6]2[CH2:5][NH:4][CH2:13][CH2:12][C:11]=2[C:10]([NH2:14])=[C:9]([N+:18]([O-:20])=[O:19])[CH:8]=1

Participants

3

Reactant 2

HCID 313Hydrochloric AcidHCID 9975520HCID 9975520, compound

Product 1

HCID 21253082HCID 21253082, compound

Procedure

A mixture of the product from Example 22 (8.8 g, 24.7 mmol) in 100 mL 6 N HCl was heated at reflux for 2.5 h. After cooling in an ice bath, the yellow precipitate was collected by filtration, washed with diethyl ether and air dried to give 7.08 g of a yellow solid. The filtrate was concentrated to give a red orange solid (2.1 g).

Workup

  1. temperaturewas heated
  2. temperatureat reflux for 2.5 h
  3. temperatureAfter cooling in an ice bath
  4. filtrationthe yellow precipitate was collected by filtration
  5. washwashed with diethyl ether and air
  6. customdried

Sources & evidence

ORD record
ord-107497a6e6fe4335bd85014f01c9082f
Source dataset
uspto-grants-2000_05
Patent number
US06057313

Reaction notes

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