Ammonium Chloride → HCID 178513335, compound

Participants

Reaction Steps

Ethyl 4-[4-(4-hydroxyamidinophenyl)-3-oxo-1-piperazinyl]-1-piperidineacetate (0.8 g) was dissolved in 8 ml of water, and 0.21 g of lithium hydroxide monohydrate was added with ice-cooling. The mixture was stirred for 30 minutes with ice-cooling, an aqueous saturated ammonium chloride solution was added, and the mixture was concentrated. The crystals formed were collected by filtration to give 0.67 g of 4-[4-(4-hydroxyamidinophenyl)-3-oxo-1-piperazinyl]-1-piperidineacetic acid.

Provenance & Evidence