Ammonium Chloride → HCID 178513335, compound

HRID 1106493Notes

Reaction equation

HRID 1106493 reaction equation
[OH:1][NH:2][C:3]([C:5]1[CH:10]=[CH:9][C:8]([N:11]2[CH2:16][CH2:15][N:14]([CH:17]3[CH2:22][CH2:21][N:20]([CH2:23][C:24]([O:26]CC)=[O:25])[CH2:19][CH2:18]3)[CH2:13][C:12]2=[O:29])=[CH:7][CH:6]=1)=[NH:4].O.[OH-].[Li+].[Cl-].[NH4+]>O>[OH:1][NH:2][C:3]([C:5]1[CH:6]=[CH:7][C:8]([N:11]2[CH2:16][CH2:15][N:14]([CH:17]3[CH2:22][CH2:21][N:20]([CH2:23][C:24]([OH:26])=[O:25])[CH2:19][CH2:18]3)[CH2:13][C:12]2=[O:29])=[CH:9][CH:10]=1)=[NH:4]

Participants

5

Reactant 3

HCID 25517Ammonium ChlorideHCID 168937Lithium hydroxide, monohydrateHCID 178472614HCID 178472614, compound

Product 1

HCID 178513335HCID 178513335, compoundYield 90%

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

Ethyl 4-[4-(4-hydroxyamidinophenyl)-3-oxo-1-piperazinyl]-1-piperidineacetate (0.8 g) was dissolved in 8 ml of water, and 0.21 g of lithium hydroxide monohydrate was added with ice-cooling. The mixture was stirred for 30 minutes with ice-cooling, an aqueous saturated ammonium chloride solution was added, and the mixture was concentrated. The crystals formed were collected by filtration to give 0.67 g of 4-[4-(4-hydroxyamidinophenyl)-3-oxo-1-piperazinyl]-1-piperidineacetic acid.

Workup

  1. temperaturecooling
  2. temperaturecooling
  3. concentrationthe mixture was concentrated
  4. customThe crystals formed
  5. filtrationwere collected by filtration

Sources & evidence

ORD record
ord-e16188954a9c45158fb1a89dd41d7919
Source dataset
uspto-grants-2000_05
Patent number
US06057324

Reaction notes

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