Hydrochloric Acid → HCID 18788754, compound

HRID 1106504Notes

Reaction equation

HRID 1106504 reaction equation
[Cl:1][C:2]1[CH:11]=[C:10]([O:12][C:13]2[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=2)[C:9]([S:19]([CH3:22])(=[O:21])=[O:20])=[CH:8][C:3]=1[C:4]([O:6]C)=[O:5].[OH-].[Na+].Cl>CO>[Cl:1][C:2]1[CH:11]=[C:10]([O:12][C:13]2[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=2)[C:9]([S:19]([CH3:22])(=[O:21])=[O:20])=[CH:8][C:3]=1[C:4]([OH:6])=[O:5]

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 14798Sodium HydroxideHCID 12274588HCID 12274588, compound

Product 1

HCID 18788754HCID 18788754, compoundYield 89%

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

3.4 g of methyl 2-chloro-4-phenoxy-5-methylsulfonylbenzoate were dissolved in 40 ml of MeOH and 9.9 ml of a 2 N aqueous NaOH solution were added. The mixture was stirred at RT for 4 hours, adjusted to pH=1-2 using a 2 N aqueous HCl solution and extracted 3 times using 150 ml of EA each time. The organic phase was dried over Na2SO4, the solvent was removed in vacuo and 2.9 g of white crystals were obtained,

Workup

  1. extractionextracted 3 times
  2. dry with materialThe organic phase was dried over Na2SO4
  3. customthe solvent was removed in vacuo

Sources & evidence

ORD record
ord-b22af747e76b4e20883e2132091debd1
Source dataset
uspto-grants-2000_05
Patent number
US06057322

Reaction notes

Loading…