Water → HCID 21968284, compound

HRID 1106513Notes

Reaction equation

HRID 1106513 reaction equation
[OH:1][CH2:2][C@@H:3]([NH:10][C:11]1[C:20]2[C:15](=[CH:16][C:17]([O:23][CH3:24])=[C:18]([O:21][CH3:22])[CH:19]=2)[N:14]=[CH:13][N:12]=1)[C:4]1[CH:9]=[CH:8][CH:7]=[CH:6][CH:5]=1.O.[C:26](OC(=O)C)(=[O:28])[CH3:27]>>[C:26]([O:1][CH2:2][C@@H:3]([NH:10][C:11]1[C:20]2[C:15](=[CH:16][C:17]([O:23][CH3:24])=[C:18]([O:21][CH3:22])[CH:19]=2)[N:14]=[CH:13][N:12]=1)[C:4]1[CH:5]=[CH:6][CH:7]=[CH:8][CH:9]=1)(=[O:28])[CH3:27]

Participants

4

Reactant 3

HCID 962WaterHCID 7918Acetic AnhydrideHCID 9927305HCID 9927305, compound

Product 1

HCID 21968284HCID 21968284, compoundYield 90%

Procedure

A solution of (S)-4-[α-(hydroxymethyl)benzylamino]-6,7dimethoxyquinazoline (70 mg, 0.21 mmol) in acetic anhydride (2 ml) was stirred at room temperature for 3 h. Then water was added to the reaction mixture, the precipitate was filtered, washed with water and dried under vacuum. Thus pure title compound was obtained in 90% yield (71 mg).

Workup

  1. filtrationthe precipitate was filtered
  2. washwashed with water
  3. customdried under vacuum

Sources & evidence

ORD record
ord-12a96418812f419f8d557ebacdaa89cf
Source dataset
uspto-grants-2000_05
Patent number
US06057326

Reaction notes

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