Potassium Carbonate → HCID 9927305, compound

HRID 1106516Notes

Reaction equation

HRID 1106516 reaction equation
Cl.[OH:2][CH2:3][C@@H:4]([NH:11][C:12]1[C:21]2[C:16](=[CH:17][C:18]([O:24][CH3:25])=[C:19]([O:22][CH3:23])[CH:20]=2)[N:15]=[CH:14][N:13]=1)[C:5]1[CH:10]=[CH:9][CH:8]=[CH:7][CH:6]=1.C(=O)([O-])[O-].[K+].[K+]>CO>[OH:2][CH2:3][C@@H:4]([NH:11][C:12]1[C:21]2[C:16](=[CH:17][C:18]([O:24][CH3:25])=[C:19]([O:22][CH3:23])[CH:20]=2)[N:15]=[CH:14][N:13]=1)[C:5]1[CH:6]=[CH:7][CH:8]=[CH:9][CH:10]=1

Participants

4

Reactant 2

HCID 11430Potassium CarbonateHCID 70186531HCID 70186531, compound

Product 1

HCID 9927305HCID 9927305, compoundYield 90%

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

A suspension of (S)-4-[α-(hydroxymethyl)benzylamino]-6,7dimethoxyquinazoline hydrochloride salt (361.8 mg, 1 mmol) and potassium carbonate (276 mg, 2 mmol) in methanol (6 ml) was stirred at ambient temperature for 0.5 h. The mixture was filtered and the filtrate evaporated under vacuum. The residue was purified by column chromatography on silica gel (eluant dichloromethane/ethanol 2-6%) to give pure title compound in 90% yield.

Workup

  1. filtrationThe mixture was filtered
  2. customthe filtrate evaporated under vacuum
  3. customThe residue was purified by column chromatography on silica gel (eluant dichloromethane/ethanol 2-6%)

Sources & evidence

ORD record
ord-f399944a4bac4bb68f354d6b78ee5cf9
Source dataset
uspto-grants-2000_05
Patent number
US06057326

Reaction notes

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