Cyclopentylamine → HCID 15863852, compound

HRID 1106527Notes

Reaction equation

HRID 1106527 reaction equation
Cl[C:2]1[N:7]2[N:8]=[CH:9][C:10]([N+:11]([O-:13])=[O:12])=[C:6]2[N:5]=[C:4]([C:14]([O:16][CH2:17][CH3:18])=[O:15])[C:3]=1[CH2:19][CH2:20]Cl.[CH:22]1([NH2:27])[CH2:26][CH2:25][CH2:24][CH2:23]1>CN(C)C=O>[CH:22]1([N:27]2[C:2]3[N:7]4[N:8]=[CH:9][C:10]([N+:11]([O-:13])=[O:12])=[C:6]4[N:5]=[C:4]([C:14]([O:16][CH2:17][CH3:18])=[O:15])[C:3]=3[CH2:19][CH2:20]2)[CH2:26][CH2:25][CH2:24][CH2:23]1

Participants

4

Reactant 2

HCID 2906CyclopentylamineHCID 15863855HCID 15863855, compound

Product 1

HCID 15863852HCID 15863852, compoundYield 95.7%

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Procedure

In 12 ml of anhydrous dimethylformamide were dissolved 1.16 g (3.48 mmol) of ethyl 7-chloro-6-(2-chloroethyl)-3-nitropyrazolo[1,5-a]pyrimidine-5-carboxylate, and 2.4 ml (d=0.863, 24.32 mmol) of cyclopentylamine were added to the solution, and the resultant mixture was stirred for 4 hours at room temperature. The reaction mixture was then poured into ice water. Insoluble solids were collected by filtration, washed with water and air-dried to obtain 1.15 g (yield: 95.7%) of the intended product.

Workup

  1. additionwere added to the solution
  2. filtrationInsoluble solids were collected by filtration
  3. washwashed with water
  4. customair-dried

Sources & evidence

ORD record
ord-bd7908a8b63249269ff00f06c5c91366
Source dataset
uspto-grants-2000_05
Patent number
US06057330

Reaction notes

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