HCID 18789323, compound → HCID 18789350, compound

HRID 1106619Notes

Reaction equation

HRID 1106619 reaction equation
[CH2:1]1[C:9]2[C:4](=[CH:5][CH:6]=[CH:7][CH:8]=2)[CH2:3][CH:2]1[C:10]([NH:12][C:13]1[CH:17]=[C:16]([C:18]2[CH:23]=[CH:22][C:21]([CH:24]=[CH2:25])=[CH:20][CH:19]=2)[NH:15][N:14]=1)=[O:11]>C(O)C.[C].[Pd]>[CH2:24]([C:21]1[CH:20]=[CH:19][C:18]([C:16]2[NH:15][N:14]=[C:13]([NH:12][C:10]([CH:2]3[CH2:3][C:4]4[C:9](=[CH:8][CH:7]=[CH:6][CH:5]=4)[CH2:1]3)=[O:11])[CH:17]=2)=[CH:23][CH:22]=1)[CH3:25]

Participants

4

Reactant 1

HCID 18789323HCID 18789323, compound

Product 1

HCID 18789350HCID 18789350, compoundYield 98.6%

Reagents, catalysts & solvents 2

HCID 178418390HCID 178418390, compoundCatalystHCID 702EthanolSolvent

Procedure

3-(2-Indanyl)carbonylamino-5-(4-vinylphenyl)pyrazole (25.0 mg) was dissolved in ethanol (5.0 ml) to which was subsequently added 10% palladium-carbon (22 mg), and then the mixture was stirred under hydrogen atmosphere of 1 atmospheric pressure overnight. The catalyst was filtered off and then, the filtrate was concentrated under a reduced pressure to obtain the title compound (24.8 mg) as colorless crystals (melting point: 196-198° C.).

Workup

  1. filtrationThe catalyst was filtered off
  2. concentrationthe filtrate was concentrated under a reduced pressure

Sources & evidence

ORD record
ord-6e0b719998c041ccabfd7747b02521a8
Source dataset
uspto-grants-2000_05
Patent number
US06057335

Reaction notes

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