Hydrogen chloride-ethyl acetate → HCID 86755373, compound

HRID 1106663Notes

Reaction equation

HRID 1106663 reaction equation
[ClH:1].C(OCC)(=O)C.[O:8]1[CH2:13][CH2:12][N:11]([CH2:14][CH2:15][CH2:16][N:17]([O:20][CH2:21][CH2:22][CH:23]2[CH2:28][CH2:27][CH2:26][CH2:25][N:24]2[C:29](=[O:49])[NH:30][CH2:31][CH2:32][CH2:33][CH2:34][CH2:35][CH2:36][CH2:37][CH2:38][CH2:39][CH2:40][CH2:41][CH2:42][CH2:43][CH2:44][CH2:45][CH2:46][CH2:47][CH3:48])[CH:18]=[O:19])[CH2:10][CH2:9]1>C(OCC)(=O)C>[ClH:1].[O:8]1[CH2:13][CH2:12][N:11]([CH2:14][CH2:15][CH2:16][N:17]([O:20][CH2:21][CH2:22][CH:23]2[CH2:28][CH2:27][CH2:26][CH2:25][N:24]2[C:29](=[O:49])[NH:30][CH2:31][CH2:32][CH2:33][CH2:34][CH2:35][CH2:36][CH2:37][CH2:38][CH2:39][CH2:40][CH2:41][CH2:42][CH2:43][CH2:44][CH2:45][CH2:46][CH2:47][CH3:48])[CH:18]=[O:19])[CH2:10][CH2:9]1

Participants

4

Reactant 2

HCID 21866389Hydrogen chloride-ethyl acetateHCID 57283844HCID 57283844, compound

Product 1

HCID 86755373HCID 86755373, compound

Reagents, catalysts & solvents 1

HCID 8857Ethyl AcetateSolvent

Procedure

4N Hydrochloric acid/ethyl acetate solution (0.13 ml) was added to a solution of N-(3-morpholinopropyl)-{2-[1-(N-octadecylcarbamoyl)-2-piperidyl]ethoxy}formamide (0.200 g) in ethyl acetate (2 ml). After being stirred for 15 minutes at room temperature, the reaction mixture was concentrated. The residue was recrystallized with ethyl acetate, thereby yielding the entitled compound (0.170 g) as white crystals.

Workup

  1. concentrationthe reaction mixture was concentrated
  2. customThe residue was recrystallized with ethyl acetate

Sources & evidence

ORD record
ord-144cb27a6e484e65a876b71898b8eee0
Source dataset
uspto-grants-2000_05
Patent number
US06057337

Reaction notes

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