HCID 9830552, compound → HCID 15897854, compound

HRID 1106672Notes

Reaction equation

HRID 1106672 reaction equation
[ClH:1].C(OCC)(=O)C.[O:8]1[CH2:13][CH2:12][N:11]([CH2:14][CH2:15][CH2:16][NH:17][C:18](=[O:51])[O:19][CH2:20][CH2:21][CH:22]2[CH2:27][CH2:26][CH2:25][CH2:24][N:23]2[C:28](=[O:50])[CH2:29][CH2:30][CH2:31][CH2:32][CH2:33][CH2:34][CH2:35][CH2:36][CH2:37][CH2:38][CH2:39][CH2:40][CH2:41][CH2:42][CH2:43][CH2:44][CH2:45][CH2:46][CH2:47][CH2:48][CH3:49])[CH2:10][CH2:9]1>C(OCC)(=O)C>[ClH:1].[O:8]1[CH2:13][CH2:12][N:11]([CH2:14][CH2:15][CH2:16][NH:17][C:18](=[O:51])[O:19][CH2:20][CH2:21][CH:22]2[CH2:27][CH2:26][CH2:25][CH2:24][N:23]2[C:28](=[O:50])[CH2:29][CH2:30][CH2:31][CH2:32][CH2:33][CH2:34][CH2:35][CH2:36][CH2:37][CH2:38][CH2:39][CH2:40][CH2:41][CH2:42][CH2:43][CH2:44][CH2:45][CH2:46][CH2:47][CH2:48][CH3:49])[CH2:10][CH2:9]1

Participants

4

Reactant 2

HCID 9830552HCID 9830552, compoundHCID 21866389Hydrogen chloride-ethyl acetate

Product 1

HCID 15897854HCID 15897854, compound

Reagents, catalysts & solvents 1

HCID 8857Ethyl AcetateSolvent

Procedure

4N hydrochloric acid/ethyl acetate solution (1.35 ml) was added to a solution of 2-(1-docosanoyl-2-piperidyl)ethyl N-(3-morpholinopropyl)carbamate (2.800 g) in ethyl acetate (28 ml), while being cooled with ice. After being stirred for 0.5 hour, the reaction mixture was concentrated. The residue was recrystallized with ethyl acetate, thereby yielding the entitled compound (2.546 g) as white solid.

Workup

  1. temperaturewhile being cooled with ice
  2. concentrationthe reaction mixture was concentrated
  3. customThe residue was recrystallized with ethyl acetate

Sources & evidence

ORD record
ord-6e02444fd9054896a01ed8c99a92e31e
Source dataset
uspto-grants-2000_05
Patent number
US06057337

Reaction notes

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