Piperidine → HCID 18789410, compound

HRID 1106676Notes

Reaction equation

HRID 1106676 reaction equation
[NH:1]1[CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1.Cl[CH2:8][CH2:9][CH2:10][C:11]([N:13]1[CH2:18][CH2:17][CH2:16][CH2:15][CH:14]1[CH2:19][CH2:20][OH:21])=[O:12]>>[OH:21][CH2:20][CH2:19][CH:14]1[CH2:15][CH2:16][CH2:17][CH2:18][N:13]1[C:11](=[O:12])[CH2:10][CH2:9][CH2:8][N:1]1[CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1

Participants

3

Reactant 2

HCID 8082PiperidineHCID 16780845HCID 16780845, compound

Product 1

HCID 18789410HCID 18789410, compound

Procedure

Piperidine (0.83 ml) was added to the crude (0.975 g) of 4-chloro-1-[2-(2-hydroxyethyl)piperidino]-1-butanone. After being stirred for 3.5 hours at 70~80° C., the reaction mixture was concentrated, thereby yielding a crude (1.097 g) of the entitled compound as light yellow syrup.

Workup

  1. concentrationthe reaction mixture was concentrated

Sources & evidence

ORD record
ord-401ee92866d54ded8b07a85c09971556
Source dataset
uspto-grants-2000_05
Patent number
US06057337

Reaction notes

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