2-Piperidin-2-ylethanol → HCID 18789369, compound

HRID 1106680Notes

Reaction equation

HRID 1106680 reaction equation
[OH:1][CH2:2][CH2:3][CH:4]1[CH2:9][CH2:8][CH2:7][CH2:6][NH:5]1.C1C=CC2N(O)N=NC=2C=1.[CH3:20][N:21]([CH3:28])[CH2:22][CH2:23][CH2:24][C:25]([O-])=[O:26]>CN(C)C=O>[CH3:20][N:21]([CH3:28])[CH2:22][CH2:23][CH2:24][C:25]([N:5]1[CH2:6][CH2:7][CH2:8][CH2:9][CH:4]1[CH2:3][CH2:2][OH:1])=[O:26]

Participants

5

Reactant 3

HCID 151442-Piperidin-2-ylethanolHCID 757711-HydroxybenzotriazoleHCID 22388951HCID 22388951, compound

Product 1

HCID 18789369HCID 18789369, compound

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Procedure

2-(2-Hydroxyethyl)piperidine, HOBt and WSCI are added to N,N-dimethylformamide solution of 4-(dimethylamino)butyrate while being cooled with ice and the mixture is reacted at room temperature to obtain 1-[4-(dimethylamino)butanoyl]-2-(2-hydroxyethyl)piperidine.

Workup

  1. temperaturewhile being cooled with ice
  2. customthe mixture is reacted at room temperature

Sources & evidence

ORD record
ord-87ffb303cc7043ba9404826b44c751ac
Source dataset
uspto-grants-2000_05
Patent number
US06057337

Reaction notes

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