4-Toluenesulfonyl chloride → HCID 18789399, compound

HRID 1106683Notes

Reaction equation

HRID 1106683 reaction equation
[OH:1][CH2:2][CH2:3][CH:4]1[CH2:9][CH2:8][CH2:7][CH2:6][N:5]1[C:10](=[O:28])[CH2:11][CH2:12][CH2:13][CH2:14][CH2:15][CH2:16][CH2:17][CH2:18][CH2:19][CH2:20][CH2:21][CH2:22][CH2:23][CH2:24][CH2:25][CH2:26][CH3:27].[C:29]1([CH3:39])[CH:34]=[CH:33][C:32]([S:35](Cl)(=[O:37])=[O:36])=[CH:31][CH:30]=1.[OH-].[Na+]>O1CCOCC1>[C:10]([N:5]1[CH2:6][CH2:7][CH2:8][CH2:9][CH:4]1[CH2:3][CH2:2][O:1][S:35]([C:32]1[CH:33]=[CH:34][C:29]([CH3:39])=[CH:30][CH:31]=1)(=[O:37])=[O:36])(=[O:28])[CH2:11][CH2:12][CH2:13][CH2:14][CH2:15][CH2:16][CH2:17][CH2:18][CH2:19][CH2:20][CH2:21][CH2:22][CH2:23][CH2:24][CH2:25][CH2:26][CH3:27]

Participants

5

Reactant 3

HCID 73974-Toluenesulfonyl chlorideHCID 14798Sodium HydroxideHCID 18789376HCID 18789376, compound

Product 1

HCID 18789399HCID 18789399, compound

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent

Procedure

1,4-Dioxane solution of 1-[2-(2-hydroxyethyl)piperidino]octadecan- 1-one and p-toluenesulfonyl chloride is added to sodium hydroxide solution and the mixture is reacted at room temperature to obtain 1-octadecanoyl-2-[2-(tosyloxy)ethyl]piperidine.

Workup

  1. customthe mixture is reacted at room temperature

Sources & evidence

ORD record
ord-e18c77868f9247799aae096d3116a976
Source dataset
uspto-grants-2000_05
Patent number
US06057337

Reaction notes

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