Hydrochloric Acid → HCID 54372821, compound

HRID 1106900Notes

Reaction equation

HRID 1106900 reaction equation
C([O:5][C:6](=[O:36])[CH2:7][O:8][C:9]1[CH:14]=[CH:13][CH:12]=[C:11]([C@H:15]([N:22]([C:24](=[O:35])[CH2:25][C:26]2[C:30]3[CH:31]=[CH:32][CH:33]=[CH:34][C:29]=3[O:28][CH:27]=2)[CH3:23])[CH2:16][N:17]2[CH2:21][CH2:20][CH2:19][CH2:18]2)[CH:10]=1)(C)(C)C.Cl>ClCCl>[O:28]1[C:29]2[CH:34]=[CH:33][CH:32]=[CH:31][C:30]=2[C:26]([CH2:25][C:24]([N:22]([CH3:23])[C@@H:15]([C:11]2[CH:10]=[C:9]([CH:14]=[CH:13][CH:12]=2)[O:8][CH2:7][C:6]([OH:36])=[O:5])[CH2:16][N:17]2[CH2:21][CH2:20][CH2:19][CH2:18]2)=[O:35])=[CH:27]1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 54020169HCID 54020169, compound

Product 1

HCID 54372821HCID 54372821, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

To a solution of Example 18 (1.272 g, 2.58 mmol) in dichloromethane (10 mL) was added HCl (2.5 mL of 4 M solution in dioxan). After stirring for 24 hours, all volatiles were removed in vacuo and the resulting solid washed with acetonitrile. After removing the solvent, the resulting solid was dried to give a beige solid, 0.50 g.

Workup

  1. customall volatiles were removed in vacuo
  2. washthe resulting solid washed with acetonitrile
  3. customAfter removing the solvent
  4. customthe resulting solid was dried
  5. customto give a beige solid, 0.50 g

Sources & evidence

ORD record
ord-150a43c1fd8b476b810454cd3604e098
Source dataset
uspto-grants-2000_05
Patent number
US06057357

Reaction notes

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