HCID 70298427, compound → HCID 70298102, compound

HRID 1106903Notes

Reaction equation

HRID 1106903 reaction equation
[CH:1]1[O:2][C:3]([CH2:10][C:11]([N:13]([CH:15]([C:30]2[CH:35]=[CH:34][CH:33]=[C:32]([O:36]CC3C=CC=CC=3)[CH:31]=2)[CH2:16][N:17]2[CH2:21][CH2:20][CH:19]([O:22][Si:23]([C:26]([CH3:29])([CH3:28])[CH3:27])([CH3:25])[CH3:24])[CH2:18]2)[CH3:14])=[O:12])=[C:4]2[CH:9]=[CH:8][CH:7]=[CH:6][C:5]=12>C(O)C.[Pd]>[CH:1]1[O:2][C:3]([CH2:10][C:11]([N:13]([CH:15]([C:30]2[CH:35]=[CH:34][CH:33]=[C:32]([OH:36])[CH:31]=2)[CH2:16][N:17]2[CH2:21][CH2:20][CH:19]([O:22][Si:23]([C:26]([CH3:28])([CH3:29])[CH3:27])([CH3:24])[CH3:25])[CH2:18]2)[CH3:14])=[O:12])=[C:4]2[CH:9]=[CH:8][CH:7]=[CH:6][C:5]=12

Participants

4

Reactant 1

HCID 70298427HCID 70298427, compound

Product 1

HCID 70298102HCID 70298102, compound

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 702EthanolSolvent

Procedure

A solution of Example 24 (3.00 g, 5.01 mmol) in absolute ethanol (50 mL) with palladium on charcoal (0.34 g) was hydrogenated at 30° C. and 50 psi for 5.5 hours. The catalyst was removed by filtration through Celite and the filtrate concentrated in vacuo to give the product, 2.195 g. This was used without further purification.

Workup

  1. customwas hydrogenated at 30° C.
  2. customThe catalyst was removed by filtration through Celite
  3. concentrationthe filtrate concentrated in vacuo
  4. customto give the product, 2.195 g
  5. customThis was used without further purification

Sources & evidence

ORD record
ord-23a79818a19e4b2ca55f5236745feaa9
Source dataset
uspto-grants-2000_05
Patent number
US06057357

Reaction notes

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