Hydrochloric Acid → HCID 70298437, compound

HRID 1106908Notes

Reaction equation

HRID 1106908 reaction equation
C([O:5][C:6](=[O:37])[CH2:7][O:8][C:9]1[CH:14]=[CH:13][CH:12]=[C:11]([CH:15]([N:23]([C:25](=[O:36])[CH2:26][C:27]2[O:28][C:29]3[CH:35]=[CH:34][CH:33]=[CH:32][C:30]=3[CH:31]=2)[CH3:24])[CH2:16][N:17]2[CH2:21][CH2:20][CH:19]([OH:22])[CH2:18]2)[CH:10]=1)(C)(C)C.Cl>ClCCl>[O:28]1[C:29]2[CH:35]=[CH:34][CH:33]=[CH:32][C:30]=2[CH:31]=[C:27]1[CH2:26][C:25]([N:23]([CH3:24])[CH:15]([C:11]1[CH:10]=[C:9]([CH:14]=[CH:13][CH:12]=1)[O:8][CH2:7][C:6]([OH:37])=[O:5])[CH2:16][N:17]1[CH2:21][CH2:20][CH:19]([OH:22])[CH2:18]1)=[O:36]

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 70299251HCID 70299251, compound

Product 1

HCID 70298437HCID 70298437, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

To a solution of Example 32 (0.824 g, 1.62 mmol) in dichloromethane (15 mL) was added HCl (3 mL of 4 M solution in dioxan). After stirring for 22 hours, all volatiles were removed in vacuo, and the resulting solid was washed with ethyl acetate (twice). The remaining solid was dissolved in acetonitrile and treated with diethyl ether. The precipitate was allowed to settle and the supernatant discarded. The solid was dried to give the product as an off-white solid.

Workup

  1. customall volatiles were removed in vacuo
  2. washthe resulting solid was washed with ethyl acetate (twice)
  3. dissolutionThe remaining solid was dissolved in acetonitrile
  4. additiontreated with diethyl ether
  5. customThe solid was dried

Sources & evidence

ORD record
ord-ee684bf8767145cd8a18971cc4b3381d
Source dataset
uspto-grants-2000_05
Patent number
US06057357

Reaction notes

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