HCID 11015313, compound → HCID 18788111, compound

HRID 1106915Notes

Reaction equation

HRID 1106915 reaction equation
C(OC([N:11]1[CH2:23][CH2:22][C:21]2[C:20]3[C:15](=[CH:16][CH:17]=[CH:18][CH:19]=3)[N:14]([CH2:24][C:25]([O:27][C:28]([CH3:31])([CH3:30])[CH3:29])=[O:26])[C:13]=2[CH2:12]1)=O)C1C=CC=CC=1>[Pd].CO>[C:28]([O:27][C:25]([CH2:24][N:14]1[C:15]2[C:20](=[CH:19][CH:18]=[CH:17][CH:16]=2)[C:21]2[CH2:22][CH2:23][NH:11][CH2:12][C:13]1=2)=[O:26])([CH3:31])([CH3:29])[CH3:30]

Participants

4

Reactant 1

HCID 11015313HCID 11015313, compound

Product 1

HCID 18788111HCID 18788111, compound

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 887MethanolSolvent

Procedure

2-Benzyloxycarbonyl-9-tert-butyloxycarbonylmethyl-1,2,3,4-tetrahydro-9H-pyrido-[3,4-b]indole (3.28 g, 7.81 mmol) was stirred under an atmosphere of hydrogen in the presence of 10% palladium on charcoal (500 mg) in methanol (30 ml) at room temperature for two hours. The reaction mixture was filtered through a pad of celite and evaporated to dryness affording the product. (2.14 g, 96%).

Workup

  1. filtrationThe reaction mixture was filtered through a pad of celite
  2. customevaporated to dryness
  3. customaffording the product

Sources & evidence

ORD record
ord-7e05433fc5c249d898fbeaa1ca8ff2df
Source dataset
uspto-grants-2000_05
Patent number
US06057311

Reaction notes

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