反应详情

A solution of 9-benzyl-2-tert-butyloxycarbonyl-1,2,3,4-tetrahydro-9H-pyrido[3,4-b]-indole (3.66 g, 10.1 mmol) in chloroform (50 ml) was stirred with trifluoroacetic acid (20 ml) at room temperature for 2 hours. The mixture was evaporated to dryness and the residue partitioned between chloroform and saturated potassium carbonate solution (150 ml/1:2). The organic layer was separated and dried (MgSO4). Filtration and evaporation of the solvent gave the product. (2.66 g, 100%).

1. customThe mixture was evaporated to dryness
2. customthe residue partitioned between chloroform and saturated potassium carbonate solution (150 ml/1:2)
3. customThe organic layer was separated
4. dry with materialdried (MgSO4)
5. filtrationFiltration and evaporation of the solvent
6. customgave the product