Trifluoroacetic acid → HCID 18788126, compound

HRID 1106921Notes

Reaction equation

HRID 1106921 reaction equation
C(OC([N:8]1[C:16]2[CH:17]=[CH:18][CH:19]=[CH:20][C:15]=2[C:14](=[O:21])[CH2:13][CH2:12][N:11]([C:22](=[O:31])[NH:23][C:24]2[CH:29]=[CH:28][CH:27]=[C:26]([CH3:30])[CH:25]=2)[CH2:10][C:9]1=[O:32])=O)(C)(C)C.F[C:34](F)(F)[C:35]([OH:37])=[O:36]>C(Cl)(Cl)Cl>[C:35]([CH2:34][N:8]1[C:16]2[CH:17]=[CH:18][CH:19]=[CH:20][C:15]=2[C:14](=[O:21])[CH2:13][CH2:12][N:11]([C:22](=[O:31])[NH:23][C:24]2[CH:29]=[CH:28][CH:27]=[C:26]([CH3:30])[CH:25]=2)[CH2:10][C:9]1=[O:32])([OH:37])=[O:36]

Participants

4

Reactant 2

HCID 6422Trifluoroacetic acidHCID 18788150HCID 18788150, compound

Product 1

HCID 18788126HCID 18788126, compound

Reagents, catalysts & solvents 1

HCID 6212ChloroformSolvent2×

Procedure

A solution of 1-tert-butyloxycarbonyl-4-(3-methylphenyl)carbamyl-2,7-dioxo-2,3,4,5,6,7-hexahydro-1H-1,4-benzodiazonine (452 mg, 1.0 mmol) in chloroform (4 ml) was stirred with trifluoroacetic acid (4 ml) at room temperature for 2 hours. The mixture was evapoarted to dryness and the residue dissolved in chloroform (50 ml), washed with brine (3×40 ml), and dried (MgSO4). Filtration and evaporation of the solvent gave the product. (393 mg, 99%).

Workup

  1. washwashed with brine (3×40 ml)
  2. dry with materialdried (MgSO4)
  3. filtrationFiltration and evaporation of the solvent
  4. customgave the product

Sources & evidence

ORD record
ord-80f80a2c000f478a821c4231f1f73883
Source dataset
uspto-grants-2000_05
Patent number
US06057311

Reaction notes

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